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When comparing Humalog vs Novolog, both are rapid-acting insulins used to manage blood glucose levels in diabetes. Humalog, with its active ingredient insulin lispro, and Novolog, containing insulin aspart, work similarly by quickly lowering blood sugar after meals. However, subtle differences in onset and duration can affect individual preferences. Humalog generally starts working a bit faster, while Novolog might have a slightly longer duration. Ultimately, the choice between Humalog vs Novolog should be guided by personal medical needs and a healthcare provider's recommendation.